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Tag "Genetics"

Studying the Few to Serve the Many: Studying the rare Gaucher disease to discover molecular mechanisms behind the common Parkinson’s Disease

Studying the Few to Serve the Many: Studying the rare Gaucher disease to discover molecular mechanisms behind the common Parkinson’s Disease

Yale scientists found two potential enzymes to target via cell therapy to treat the common variety of Parkinson’s disease associated with Gaucher disease. These two enzymes regulate the pathology of the specific lipids that accumulate due to Gaucher disease.

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Demystifying the Genes Behind Breast Cancer

Demystifying the Genes Behind Breast Cancer

It’s taken over two decades to fit together pieces of information about the BRCA genes behind breast and ovarian cancer. Researchers in the Sung Lab at Yale University, led by Patrick Sung and Weixing Zhao, have tackled the problem by developing a way to study proteins, which led to discovering the function of BRCA1 and its interaction with other genes in the role of tumor expression.

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Science in the Spotlight: How to Tame a Fox (And Build a Dog)

Science in the Spotlight: How to Tame a Fox (And Build a Dog)

They greet their owners at the door with leaps and wagging tails, begging for pats. Read Lee Dugatkin and Lyudmila Trut’s account of how they tamed the fox and why it matters.

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How Genes Affect Your Flu Vaccines

How Genes Affect Your Flu Vaccines

A national study has confirmed a genetic link to our bodies’ responses to the flu vaccine. Yale Associate Professor of Medicine Ruth Montgomery explains the significance of this discovery to the future of vaccination.

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Not So Tumor Suppressant: How a single gene can both promote and suppress tumor growth

Not So Tumor Suppressant: How a single gene can both promote and suppress tumor growth

Tet2, a gene believed to be a tumor suppressor since 2009, may also have tumor-promoting effects on other types of cancer, raising some interesting questions about what it means to be a tumor suppressor and how Tet2 could affect different cancer treatments.

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Giving Genes PiggyBac Rides

Giving Genes PiggyBac Rides

New technology that enables certain segments of DNA to “jump” around the genome via a cut and paste method can serve as a more cost-effective, time-efficient alternative to using STEM cells

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A New Map of the Body: Profiling Gene Expression Levels across Human Tissues

A New Map of the Body: Profiling Gene Expression Levels across Human Tissues

The Genotype-Tissue Expression (GTEx) project aims to characterize the gene expression profiles of different human tissues. The resulting gene expression map could help clarify how genetic variations work at a molecular level to influence gene expression.

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Hiding Transplants from Our Immune Systems: Nanoparticles deliver gene-suppressor, decreasing risk of transplant rejection

Hiding Transplants from Our Immune Systems: Nanoparticles deliver gene-suppressor, decreasing risk of transplant rejection

Yale researchers develop a nanoparticle delivery system that releases a siRNA capable of protecting transplanted organs from rejection by the immune system. The nanoparticles have the potential to inhibit immune system’s recognition of transplants.

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How was Wheat Domesticated?

How was Wheat Domesticated?

Researchers at Tel Aviv University have been studying the genomics of wheat to determine how it was domesticated.

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Nature and Nurture: Reclassifying diseases by genetic and environmental factors

Nature and Nurture: Reclassifying diseases by genetic and environmental factors

A comparison of genetic and environmental correlations between twenty-nine diseases reveals unforeseen similarities that transform both the classification and potentially treatments of complex diseases.

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