For parents whose children are at risk of inheriting a mitochondrial disorder, genetic material from a third person can help them conceive a healthy child. Mitochondria are maternally inherited organelles, so if a mother’s mitochondrial DNA is mutated, her children
The Isaacs Lab on Yale University’s West Campus are recoding the genomes of bacteria so that they are resistant to viral infections. The research could pave the way for more secure biofactories.
For many years, gene editing has been hailed as the future of medicine. As the genetic basis of disease becomes clearer, researchers continue to discover more ways to alter the genome and prevent or cure diseases. Recently, a new gene
Tackling Inflammation at its Genetic Roots: Applying Personalized Medicine to Autoimmunity and Cancer
Yale researchers, led by professor of medicine Richard Bucala, have discovered that the transcription factor, ICBP90, governs the disease-causing aspect of a key inflammatory gene. This discovery has spurred new drug development efforts for patients of inflammatory and autoimmune diseases as well as cancer.
Alumnus Francis Collins (PhD ’74) initially held little interest for the field of biology. Yet he went on to successfully direct the Human Genome Project, the largest endeavor in genetic research. Collins now serves as Director of the NIH, the largest contributor to medical research in the world.
Early forensic science was based on guesswork and rudimentary identification techniques. Since the 1984 invention of DNA fingerprinting, analysts have been able to determine guilt with ever-increasing certainty.
A recent study published in Nature Biotechnology by a Yale University team revealed an efficient way for building new classes of biomaterials containing nonstandard amino acids.
AACR directors Patricia LoRusso of the Yale School of Medicine, George D. Demetri of the Dana-Farber Cancer Institute and Victor Velculescu of the Johns Hopkins Kimmel Comprehensive Cancer Center are working to implement a “moonshot” for cancer initiative to produce innovative breakthroughs.
Revealing the Human Catalogue: Eight-year effort to catalogue human genetic variation comes to an end
Does genetic mutation inevitably cause disease? After eight years of research, the 1000 Genomes Project has found that healthy humans show much more variation than previously thought.
Contrary to common scientific belief, proteins need not be large to have powerful biological functions.