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Targeting the Mitochondria: Articulating Safety to Combat Liver Disease

Targeting the Mitochondria: Articulating Safety to Combat Liver Disease

Nonalcoholic fatty liver disease (NAFLD), which afflicts up to one-third of the general adult population, is swiftly becoming the most common cause of chronic liver disease. NAFLD is also associated with type 2 diabetes and cardiovascular disease. In a Yale-spearheaded

SAUCIE: An Innovative Beginning For Single Cell Analysis

SAUCIE: An Innovative Beginning For Single Cell Analysis

In the digital era, large amounts of data are collected without efficient means to analyze the information, especially in medicine. To solve this problem, a group of scientists, led by Professor Smita Krishnaswamy of Yale University, created SAUCIE (Sparse Autoencoder

Paired Growth: What stars reveal about black holes

Paired Growth: What stars reveal about black holes

Black holes, with intense gravity that even light cannot escape, have long intrigued astronomers and physicists. These black holes often lie at the center of galaxies, gradually pulling in stellar material. Previous research found proof of a positive correlation between

Long Live the Organoids: How researchers induced vascularization in brain organoids to enhance their maturity

Long Live the Organoids: How researchers induced vascularization in brain organoids to enhance their maturity

Through cutting-edge advancements in the field of genetics, researchers are now able to grow three-dimensional models of organs, called organoids, using in-vitro methods. Generating organoids for the human brain has become a pioneering research effort, especially the use of human

Targeting Tumors with RNA: An elegant collaboration between RNA structure and immunology

Targeting Tumors with RNA: An elegant collaboration between RNA structure and immunology

Cancer is the second-largest killer in America and one of the most difficult diseases to treat. How do we possibly target cancer cells when they appear almost exactly the same as our own healthy cells? Recently, two Yale research groups

Not-Dehydrated Squirrels:  How Hibernating Squirrels Stay Hydrated

Not-Dehydrated Squirrels: How Hibernating Squirrels Stay Hydrated

Humans are thirsty animals—it’s built into our DNA. But have you ever thought about what happens in your body when you feel an overpowering urge to quench your thirst? Thirst is triggered by a surge in compounds which affect the

Iron With Three Arms

Iron With Three Arms

In biological systems, iron-sulfur (Fe-S) clusters act as components of electron transfer proteins. These clusters occur in various different forms, including cubanes (4Fe-4S) and diamond (2Fe-2S) structures. All known iron-sulfur clusters yield high-spin electron configurations, meaning that one electron is

RIG-Ing the Immune System: Discovering the mechanisms of immune receptor activation

RIG-Ing the Immune System: Discovering the mechanisms of immune receptor activation

The human immune system is widely studied due to its integral role in health, from preventing infection to the development of autoimmune diseases. At Yale University, Professor Anna Pyle’s lab is specifically interested in the function of innate immune receptor